https://www.shraddhapailab.com/news-reel daily 0.75 2025-07-14 https://www.shraddhapailab.com/news-reel/g8bgu7xasmt2w8vll5yve1lrivnqk9 monthly 0.5 2025-07-14 https://www.shraddhapailab.com/news-reel/ir24rw5x2e1qkbhqrsm6zqddjcet4h monthly 0.5 2025-04-09 https://www.shraddhapailab.com/news-reel/our-first-batch-of-human-cerebellar-organoids monthly 0.5 2025-02-20 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/b51cb22e-ef79-4bc8-a61f-2dccc71ffea0/hCerO_32Day_IFs.png NEWS - our first batch of human cerebellar organoids! - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.shraddhapailab.com/news-reel/award-prostate-cancer-predict monthly 0.5 2025-02-20 https://www.shraddhapailab.com/home daily 1.0 2024-03-21 https://www.shraddhapailab.com/our-team daily 0.75 2025-09-11 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/8f35f1c9-2b22-4f52-9d54-c856fc03de9c/EllenMak.jpg Our team 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https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/524df200-3bf1-4004-9521-3ea415687ad9/IanCheong.jpg Our team https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/3c62e2c2-d7a4-4a0e-bd46-d4e347c55e56/YuxiYang.JPG Our team https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/085ac727-85c3-4e43-af77-448a3f40f4f2/Nikoo_Photo.png Our team https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/8d18fe54-1095-4c5d-b577-835be1ff022a/NourHassan.png Our team https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/07a3a407-e1e0-4824-8983-47bec0166e4a/detective-svgrepo-com.png Our team https://www.shraddhapailab.com/our-research-and-projects daily 0.75 2024-07-10 https://www.shraddhapailab.com/publications daily 0.75 2025-05-14 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/57b1164e-f4ee-48f1-a5c6-7456b166858f/Screenshot+2025-12-09+at+3.14.51%E2%80%AFPM.png PUBLICATIONS PREPRINT: 2025: First report of DNA methylomes in human cerebellar glutamatergic neural progenitors. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/8491e89d-8961-4439-8d05-ab02c8f8f513/Screenshot+2025-05-14+at+9.47.57%E2%80%AFAM.png PUBLICATIONS PREPRINT: 2025: First report of BRCA1 widely expressed in developing human brain and in Group 3 and 4 medulloblastoma https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/27915fea-f918-4e49-a515-bca68fbf09ff/Screenshot+2025-05-14+at+9.53.33%E2%80%AFAM.png PUBLICATIONS 2025: Ian Cheong's MSc Thesis, Medical Biophysics, University of Toronto: Human and mouse unipolar brush cells and relevance to Group 4 medulloblastoma https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/20041340-b1bd-47e6-b7a5-9dab3031924a/Screenshot+2025-05-14+at+9.55.51%E2%80%AFAM.png PUBLICATIONS 2023: Fourteen quick tips for crowdsourcing geographically linked data for public health advocacy https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/a14e1563-84a2-4e88-a5cd-e4a12a52cd5e/Screenshot+2025-05-14+at+10.08.01%E2%80%AFAM.png PUBLICATIONS 2023: Systems biology of the genetics of peri-adolescent cognition https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/cd595678-6da4-4f30-84e1-de61a08c9828/Screenshot+2025-05-14+at+10.05.33%E2%80%AFAM.png PUBLICATIONS 2019: Long-range epigenetic dysregulation of dopamine synthesis identified from first epigenome-wide association study in major psychosis https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/9baa4ba6-03b7-4640-8d6c-f7d05859fc6c/Screenshot+2025-05-14+at+10.09.54%E2%80%AFAM.png PUBLICATIONS 2019: Algorithm and software for patient classification using multimodal data integration and machine learning https://www.shraddhapailab.com/about daily 0.75 2024-04-26 https://www.shraddhapailab.com/contact daily 0.75 2024-04-26 https://www.shraddhapailab.com/news-2 daily 0.75 2024-01-10 https://www.shraddhapailab.com/gallery daily 0.75 2024-03-28 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/f9534f5c-f423-420d-8ed3-341692a1cab2/IMG_1559.jpg Gallery When you unexpectedly both give each other single-cell RNAseq mugs ... https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/3b0a5424-46ad-411c-8ea2-481976de413f/20250425_181002672.jpg Gallery Farewell Ian Cheong and Yuxi Yang! Featuring mango cake and strawberry KitKats from Japan. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/1740080949961-TN6V75OMHT3D097PB7SJ/hCerO_32Day_IFs.png Gallery The lab generates its first batch of human cerebellar organoids, in collaboration with Dr. Liliana Attisano's Applied Organoid core. The organoid contains BARHL1+ neurons which mark the rhombic lip progenitor niche which, when dysregulated, are hypothesized to give rise to forms of medulloblastoma. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/c384a3e2-5dfe-4760-8aee-650b015368ec/IMG_20240501_144438.jpg Gallery PhD candidate Xinghan Sun presents his thesis work on non-coding mutations in Group 3 and 4 medulloblastoma, at the 2024 UofT Medical Biophysics Symposium in Toronto. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/d858ecc3-727d-405c-b410-7cfd7704e3c2/IMG_20240501_120023.jpg Gallery PhD candidate Jaskirat Singh Sandhu presents his thesis work on small molecule screens in recurrent glioblastoma at the 2024 UofT Medical Biophysics symposium. May 1 2024. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/959d1c29-0ab1-4ef9-a1de-ac41a9d92438/IMG_4399.jpeg Gallery McMaster University co-op trainee Ellen Mak presents her work optimizing CRISPRi in pediatric brain cancer cell lines at the 2024 OICR Translational Research Conference in King City, ON. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/4cf1a408-b92e-45e4-97c1-0dede95e4ed6/IMG_6067.jpg Gallery Lab trip to Canada's Wonderland, Summer 2024. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/ca08d796-0040-46fb-b381-3b311c11c310/IMG_2423.jpg Gallery Laser-capture microdissection of developing human hindbrain with Alexandria Albano of OICR Tissue Portal https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/24899f3b-c403-4371-9b5c-f452854c5b30/IMG_2426.jpg Gallery Laser-capture microdissection of developing human hindbrain with Alexandria Albano of OICR Tissue Portal https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/1706742967835-NEA8DAR6Q9PYH5HAOOAO/Screenshot%2B2024-01-31%2Bat%2B6.14.24%2BPM.jpg Gallery Imaging medulloblastoma cells after CRISPRi knockdown. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/4c617c87-be24-4a60-b716-f8d168ea6e7a/IMG_5363.jpg Gallery McMaster University co-op trainee Hana Hajari maintains pediatric brain cancer cells engineered for CRISPRi genetic perturbation. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/f8416d0e-e44b-4277-9ad8-326f21117309/2023_CEEHRC_Ian_IMG_2110.jpg Gallery Ian Cheong presents his single-cell genomics work on developmental origins of medulloblastoma https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/5ff59a3a-0081-4d10-b9b5-f5a23b5c9f33/IMG_0992.jpg Gallery Celebrating our first CRISPRi knockdown! https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/19cde500-e507-46d8-aad7-b72700d55983/CCRC_Shraddha.jpg Gallery Talking epigenomics of childhood brain cancer at the 2023 Canadian Cancer Research Conference in Halifax https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/761b96c0-cfeb-4090-821b-5bf94bc8448d/IMG_2600.jpg Gallery Escaping 2023. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/6feb819a-585e-42ee-a7e2-ce53d0bc5b36/Screenshot+2024-01-31+at+6.19.33+PM.png Gallery Developing hindbrain showing actively dividing cells. The cells of origin of medulloblastoma are towards the bottom of the section. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/1d179465-7f10-48e0-a69e-454f8f304762/2023_CIHRNewPI+-+2%5B12%5D.jpg Gallery Shraddha with a cohort of new PIs at the CIHR New PI meeting in Halifax. https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/750f07ee-899e-4026-ba69-705e3b646cc6/Image%5B87%5D.jpeg Gallery University of Waterloo co-op student Alex Chan tries his hand at laser-capture microdissection https://www.shraddhapailab.com/publications-1 daily 0.75 2025-02-20 https://www.shraddhapailab.com/team-lead daily 0.75 2025-07-14 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/a6170774-7d2c-4935-9bd7-ca170fea15f0/SP_Apr2024_208_better.jpg https://www.shraddhapailab.com/our-funders daily 0.75 2025-07-14 https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/726e7639-2b8b-45e5-9f19-2ab2179fc6e4/OICR+Logo_RGB_ENGLISH.png https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/1108e4bd-05d9-4257-ae35-7806e2803236/NSERC_RGB.jpg https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/1739ad8a-53c3-45d4-8849-115bc5984c42/Screenshot+2024-02-19+at+5.09.55+PM.png https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/31b561ae-04a6-46e8-9d96-492da41df25f/FACIT_tagline_vertical_2.jpg https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/7078cc64-2caa-43e6-b37d-f034ea418ff3/GenomeCanada_transparent.png https://images.squarespace-cdn.com/content/v1/650eefb51aa9fb5b46d91c22/8355cb7f-13aa-4984-bd8e-4aea5368cc67/leaf-cihr-colour-en.jpeg